Complete and accurate prescription drug information is vitally important to support efforts to reduce the incidence of prescription drug misuse and diversion. Healthcare providers (prescribers and dispensers) have a vested interest in ensuring that quality data are transmitted to and available from prescription drug monitoring programs (PDMPs). This report examines promising practices for PDMPs in identifying the dispensers required to transmit prescription data, effective ways to monitor dispensers’ compliance, and how to provide dispensers with information about what data should be transmitted and how. It also examines where data errors may potentially occur and how PDMPs may identify the errors and processes to ensure timely corrective actions. This report details the areas where prescription data errors may occur, some procedures PDMPs employ to detect those errors, and steps to ensure that the erroneous data are corrected. In addition, it provides suggestions for prescribers, dispensers, and other stakeholders to prevent data errors from occurring.